Diseases of the Myocardium and Endocardium55. The Adaptive Immunse System41. Non-Hodgkin Lymphomas177. Thrombocytopenia164. Edited by Lee Goldman and Andrew I. Schafer, Part 1: Social and Ethical Issues in Medicine, 1: Approach to Medicine, the Patient, and the Medical Profession: Medicine as a Learned and Humane Profession, 3: Care of Dying Patients and Their Families, Part 2: Principles of Evaluation and Management, 6: Approach to the Patient: History and Physical Examination, 7: Approach to the Patient with Abnormal Vital Signs, 11: Quality of Care and Safety of Patients, 12: Comprehensive Chronic Disease Management, Part 3: Preventive and Environmental Issues, 13: Counseling and Advising for Behavior Changes, 18: Principles of Occupational and Environmental Medicine, 21: Chronic Poisoning: Trace Metals and Others, 22: Epidemiology of Aging: Implications of the Aging Society, 27: Delirium and Other Mental Status Problems in the Older Patient, 34: Immunosuppressive Drugs, Including Corticosteroids, 36: Prostaglandins, Aspirin, and Related Compounds, 38: Complementary and Alternative Medicine, 41: The Inherited Basis of Common Diseases, 42: Applications of Molecular Technologies to Clinical Medicine, Part 7: Principles of Immunology and Inflammation, 44: The Innate and Adaptive Immune Systems, 46: Mechanisms of Immune-Mediated Tissue Injury, 47: Mechanisms of Inflammation and Tissue Repair, 50: Approach to the Patient with Possible Cardiovascular Disease, 51: Epidemiology of Cardiovascular Disease, 52: Cardiac Function and Circulatory Control, 58: Heart Failure: Pathophysiology and Diagnosis, 59: Heart Failure: Management and Prognosis, 60: Diseases of the Myocardium and Endocardium, 62: Approach to the Patient with Suspected Arrhythmia, 63: Approach to Cardiac Arrest and Life-Threatening Arrhythmias, 64: Cardiac Arrhythmias with Supraventricular Origin, 66: Electrophysiologic Interventional Procedures and Surgery, 70: Atherosclerosis, Thrombosis and Vascular Biology, 72: Acute Coronary Syndrome/Unstable Angina and Non-ST Elevation MI, 73: ST-Elevation Myocardial Infarction and Complications of MI, 74: Interventional and Surgical Treatment of Coronary Artery Disease, 79: Atherosclerotic Peripheral Arterial Disease, 83: Approach to the Patient with Respiratory Disease, 85: Respiratory Structure and Function: Mechanisms and Testing, 90: Bronchiectasis, Atelectasis, Cysts, and Localized Lung Disorders, 94: Physical and Chemical Injuries of the Lung, 99: Diseases of the Diaphragm, Chest Wall, Pleura, and Mediastinum, 100: Obstructive Sleep Apnea/Hypopnea Syndrome, 101: Interventional and Surgical Approaches to Lung Disease, 102: Approach to the Patient in a Critical Care Setting, 103: Respiratory Monitoring in Critical Care, 112: Medical Aspects of Trauma and Burn Care, Robert H. Demling;Jonathan Gates;Reza Askari, 114: Venoms and Poisons from Marine Organisms, Part 11: Renal and Genitourinary Diseases, 116: Approach to the Patient with Renal Disease, 117: Structure and Function of the Kidneys, 118: Disorders of Sodium and Water Homeostasis, 121: Disorders of Magnesium and Phosphorus, 123: Glomerular Disorders and Nephrotic Syndromes, 130: Hereditary Nephropathies and Abnormalities of the Urinary Tract, 131: Benign Prostate Disease and Prostatitis, 133: Treatment of Irreversible Renal Failure, 134: Approach to the Patient with Gastrointestinal Disease, 135: Diagnostic Imaging Procedures in Gastroenterology, 137: Gastrointestinal Hemorrhage and Occult Gastrointestinal Bleeding, 138: Disorders of Gastrointestinal Motility, 139: Functional Gastrointestinal Disorders: Irritable Bowel Syndrome, Dyspepsia, and Noncardiac Chest Pain, 142: Approach to the Patient with Diarrhea and Malabsorption, 144: Inflammatory and Anatomic Diseases of theINtestine, Peritoneum, Mesentery, and Omentum, Part 13: Diseases of the Liver, Gallbladder, and Bile Ducts, 148: Approach to the Patient with Liver Disease, 149: Approach to the Patient with Jaundice or Abnormal Liver Test Results, 152: Toxin- and Drug-Induced Liver Disease, 153: Inherited and Metabolic Hepatic Disorders, 154: Bacterial, Parasitic, Fungal, and Granulomatous Liver Diseases, 155: Alcoholic and NonAlcoholic Steatohepatitis, 157: Hepatic Failure and Liver Transplantation, 158: Diseases of the Gallbladder and Bile Ducts, 159: Hematopoiesis and Hematopoietic Growth Factors, 163: Autoimmune and Intravascular Hemolytic Anemias, 164: Hemolytic Anemias: Red Cell Membrane and Metabolic Defects, 165: Hemoglobinopathies: The Thalassemias, 166: Sickle Cell Disease and Associated Hemoglobinopathies, 168: Aplastic Anemia and Related Conditions, 169: Polycythemias, Essential Thrombocythemia and Primary Myelobfibrosis, 171: Approach to the Patient with Lymphadenopathy and Splenomegaly, 174: Approach to the Patient with Bleeding and Thrombosis, 176: Von Willebrand’s Disease and Abnormalties of Vascular Function, 177: Hemorrhagic Disorders: Coagulation Factor Deficiencies, 178: Hemorrhagic Disorders: DIC, Liver Failure, and Vitamin K Deficiency, 179: Thrombotic Disorders: Hypercoagulable States, 181: Hematopoietic Stem Cell Transplantation, 186: Endocrine Manifestations of Tumors: ""Ectopic"" Hormone Production, 187: Paraneoplastic Syndromes and Other Non-Neoplastic Effects of Cancer, 195: Tumors of the CNS and Intracranial Hypertension and Hypotension, 197: Lung Cancer and Other Pulmonary Neoplasms, 198: Neoplasma of the Esophagus and Stomach, 199: Neoplasms of the Large and Small Intestine, 203: Tumors of the Kidney, Bladder, Ureters, and Renal Pelvis, 204: Breast Cancer and Differential Diagnosis of Benign Lesions, 208: Bone Tumors: Primary and Metastatic Lesions, 210: Melanoma and Nonmelanoma Skin Cancers, 212: Approach to Inborn Errors of Metabolism, 216: Homocystinuria and Hyperhomocysteinemia, 220: Nutrition's Interface with Health and Disease, 225: Vitamins, Trace Minerals, and Other Micronutrients, 228: Approach to the Patient with Endocrine Disease, 230: Neuroendocrinology and the Neuroendocrine System, 235: The Adrenal Medulla, Catecholamines, and Pheochromocytoma, 238: Hypoglycemia/Pancreatic Islet Cell Disorders, 240: Multiple-Organ Syndromes: Carcinoid Syndrome, 243: Ovaries, Development and Menstrual Cycle, 244: Reproductive Endocrinology/Infertility, 247: Common Medical Problems in Pregnancy, Part 20: Diseases of Bone and Mineral Metabolism, 253: The Parathyroid Glands, Hypercalcemia, and Hypocalcemia, 254: Medullary Thyroid Carcinoma and Calcitonin, 256: Osteonecrosis, Osteosclerosis/Hyperostosis and Other Disorders of Bone, Part 21: Diseases of Allergy and Clinical Immunology, 257: Approach to the Patient with Allergic or Immunologic Disease, 261: Systemic Anaphylaxis, Food Allergy, and Insect Sting Allergy, 264: Approach to the Patient with Rheumatic Disease, 265: Laboratory Testing in the Rheumatic Diseases, 266: Imaging Studies in the Rheumatic Diseases, 267: Connective Tissue Structure and Function, 268: Inherited Diseases of Connective Tissues, 269: The Systemic Autoinflammatory Diseases, 271: Bursitis, Tendonitis, and Other Periarticular Disorders, and Sports Medicine, 279: Polymyalgia Rheumatica and Temporal Arteritis, 280: Infections of Bursae, Joints, and Bones, 282: Fibromyalgia and Chronic Fatigue Syndrome, 283: Systemic Diseases in which Arthritis is a Feature, 285: Surgical Treatment of Joint Diseases, 286: Introduction to Microbial Disease - Host-Pathogen Interactions, 287: Principles of Anti-Infective Therapy, 288: Approach to Fever or Suspected Infection in the Normal Host, 289: Approach to Fever and Suspected Infection in the Compromised Host, 290: Approach to the Patient with Healthcare-associated Infections, 291: Approach to the Patient with Suspected Enteric Infection, 292: Approach to the Patient with Urinary Tract Infection, 293: Approach to the Patient with a Sexually Transmitted Disease, 294: Approach to the Patient Before and After Travel, 298: Non-Pneumococcal Streptococcal Infections, Rheumatic Fever, 300: Diphtheria and Other Corynebacteria Infections, 305: Diseases Caused by Non-spore-forming Anaerobic Bacteria, 308: Haemophilus and Moraxella Infections, 313: Infections due to other Members of the Enterobacteriaceae, including Management of Multi-Drug Resistant Strains, 314: Pseudomonas and Related Gram-Negative Bacillary Infections, 315: Other Non-Fermenting Gram-Negatives: Acinetobacter and Stenotrophomonas sp, 316: Salmonella Infections (Including Typhoid Fever), 319: Tularemia and Other Francisella Infections, 320: Plague and Other Yersinia Infections, 321: Whooping Cough and Other Bordetella Infections, 323: Disease Caused by Bartonella Species, 330: Relapsing Fever and Other Borrelia Infections, 354: African Trypanosomiasis (Sleeping Sickness), 355: American Trypanosomiasis (Chagas' Disease), 361: Babesiosis and Other Protozoan Diseases, 364: Liver, Intestinal, and Lung Fluke Infections, 380: Smallpox, Monkeypox, and Other Poxvirus Infections, 386: Human T-Cell Lymphotropic Viruses Type I and II, 388: Rotaviruses, Noroviruses, and Other GI Viruses, 390: Arthropod-borne Viruses Causing Fever and Rash, 391: Anthropod-borne Viruses Affecting the CNS, Part 24: HIV and the Acquired Immunodeficiency Syndrome, 392: Epidemiology of HIV Infection and AIDS, 394: Biology of Human Immunodeficiency Viruses, 397: Gastrointestinal Manifestions of HIV and AIDS, 398: Pulmonary Manifestations of HIV and AIDS, 399: Skin Manifestations in Patients with HIV Infection, 400: Hematology/Oncology in Patients with HIV Infection, 401: Neurologic Complications of HIV Infection, 402: Immune reconstitution Inflammatory Syndrome in HIV/AIDS, 403: Approach to the Patient with Neurological Disease, 404: Psychiatric Disorders in Medical Practice, 407: Spine, Disc, Spinal Cord and Spinal Root Disease, 409: Alzheimer's Disease and Other Dementias, 411: Coma, Persistent Vegetative State and Brain Death, 413: Approach to Cerebrovascular Diseases, 419: Multiple Sclerosis and Demyelinating Conditions of the CNS, 420: Meningitis: Bacterial, Viral, and Other, 421: Brain Abscess and Parameningeal Infections, 425: Nutritional and Alcohol-Related Neurologic Diseases, 426: Congenital, Developmental and Neurocutaneous Disorders, 427: Autonomic Disorders and Their Management, 430: Disorders of Neuromuscular Transmission, Part 26: Eye, Ear, Nose, and Throat Diseases, 433: Diseases of the Mouth and Salivary Glands, 434: Approach to the Patient with Nose, Sinus, and Ear Disorders, 438: Principles of Preoperative Consultation and Co-Management, 441: Postoperative Care and Complications, 444: Examination of the Skin and an Approach to Diagnosing Skin Diseases, 446: Eczema, Photosensitivity, and papulosquamous (including fungal) Diseases and Figurate Erythemas, 447: Macular, Vesiculobullous, and Pustular Diseases, 448: Urticaria, Drug Hypersensitivity Rashes, Nodules and Tumors, and Atrophic Diseases, 449: Infections, Hyper-and Hypopigmentation, Regional Dermatology, and Distinctive Lesions in Black Skin, Appendix: Laboratory Reference Intervals and Values, Appendix: Reference Intervals and Laboratory Values, Executive Vice President for Health and Biomedical Sciences and Dean of the Faculties of Health Sciences and of Medicine, Harold and Margaret Hatch Professor of the University, Professor of Medicine and of Epidemiology, Columbia University, New York, NY, Harold and Margaret Hatch Professor, Executive Vice President and Dean of the Faculties of Health Sciences and Medicine, Chief Executive, Columbia University Medical Center, Columbia University, New York, New York, Professor of Medicine, Director, Richard T. 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